Chemokine receptor antagonists

Chemokines are chemotactic cytokines, leads to leukocyte recruitment and activation. In malignancies altered expression can induce angiogenesis, tumor cell proliferation, and metastasis. Chemokine receptor antagonists inhibit chemokine receptors expressed on cancer and stromal cells.

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Types

  • Newly diagnosed multiple myeloma
  • Plasma cell dyscrasias
  • Relapsed/refractory multiple myeloma

Therapeutics

  • Auto-HSCT
  • Bortezomib
  • Carfilzomib
  • Cyclophosphamide
  • Daratumumab
  • Dexamethasone
  • Immune modulators
  • Lenalidomide
  • Motixafortide
  • Plerixafor
  • Proteasome inhibitors
  • Thalidomide

Congresses

  • ASH 2019
  • COMy 2020
  • EBMT 2020

Trials

  • ALCYONE
  • CASSIOPEIA
  • GENESIS
  • GRIFFIN
  • IFM2009
  • PERSEUS
  • SWOG S0777

Expert Opinions

Educational Resources

  • Drug approvals

All Therapeutics

Chemokine receptor antagonists

Additional Therapeutics